FITC标记的白细胞介素-12受体β1抗体
产品名称： FITC标记的白细胞介素-12受体β1抗体
英文名称： Anti-IL12RB1/FITC
产品编号： HZ-2603R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-IL12RB1/FITC Conjugated antibody
FITC标记的白细胞介素-12受体β1抗体
| 英文名称 | Anti-IL12RB1/FITC |
| 中文名称 | FITC标记的白细胞介素-12受体β1抗体 |
| 别 名 | Interleukin-12 receptor subunit beta-1; IL12RB1; IL-12RB1; CD212; IL-12R-BETA1; IL12RB; MGC34454; IL-12 receptor beta component; interleukin-12 receptor beta-1 chain; IL-12RB1; IL-12R-beta-1; IL-12R subunit beta-1; IL-12 receptor subunit beta-1; I12R1_MOUSE. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 细胞膜受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Mouse, Rat, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 80kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse IL-12RB1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq]. Function: Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade. Subunit: Dimer or oligomer; disulfide-linked. Interacts with IL12RB2 to form the high affinity IL12 receptor. Heterodimer with IL23R; in presence of IL23. The heterodimer forms the IL23 receptor. Subcellular Location: Membrane; Single-pass type I membrane protein. Similarity: Belongs to the type I cytokine receptor family. Type 2 subfamily. Contains 5 fibronectin type-III domains. Database links: Entrez Gene: 16161 Mouse Entrez Gene: 171333 Rat SwissProt: Q60837 Mouse Unigene: 731 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因编码的蛋白属于Ⅰ型跨膜蛋白，属于造血素受体超家族。这种蛋白与低亲和力的白介素12（IL12）结合，被认为是IL12受体复合物的一部分。该蛋白质形成二硫键连接的低聚物，其IL12结合活性是必需的。这和IL12RB2蛋白的共表达显示导致高亲和力的IL12结合位点的形成和IL12依赖信号的重建。缺乏该基因的表达导致严重的分枝杆菌和沙门氏菌感染患者的免疫缺陷。已经报道了编码不同亚型的该基因的两个交替剪接转录变体。[由RefSeq提供]。