分子量:37.7 kDa

纯度:>85% as determined by SDS-PAGE.

内毒素:Less than 1.0 EU per μg of the Human IL-5 R alpha, His Tag by the LAL method.

Buffer:PBS, pH7.4

生物活性:

产品特性:Human IL-5 R alpha, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 37.7 kDa. The predicted N-terminus is Asp 21. The reducing (R) protein migrates as 45-55 kDa in SDS-PAGE  due to glycosylation.

产品背景:Interleukin-5 receptor subunit alpha (IL5RA) is also known as IL-5 receptor subunit alpha, IL-5R subunit alpha and CD125,which is a single-pass type I membrane protein that belongs to the type I cytokine receptor family and type 5 subfamily.IL5R, a heterodimer of an alpha and a beta subunit, is expressed on eosinophils and basophils. IL5RA / CD125 is the receptor for interleukin-5 (IL5) and the alpha chain can bind to IL5. The WSXWS motif of IL5RA appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.The beta subunit of IL5R is common to the IL3, IL5 and GM-CSF receptors.