FITC标记的UBXN2B蛋白抗体
产品名称： FITC标记的UBXN2B蛋白抗体
英文名称： Anti-UBXN2B/FITC
产品编号： HZ-13680R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-UBXN2B/FITC Conjugated antibody
FITC标记的UBXN2B蛋白抗体
| 英文名称 | Anti-UBXN2B/FITC |
| 中文名称 | FITC标记的UBXN2B蛋白抗体 |
| 别 名 | NSFL1 cofactor p37; p37; p97 cofactor p37; UBX domain containing protein 2B; UBX domain protein 2B; UBX domain-containing protein 2B; UBX2B_HUMAN; UBXN2B |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 泛素 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 37kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human UBXN2B |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The UBX (Ubiquitin regulatory X) domain is an 80 amino acid motif that is usually present on the carboxy-terminus of certain eukaryotic proteins. UBX domain-containing proteins (UBXD), such as FAF1, p33ING1 and D8S2298E, are typically involved in ubiquitin-related processes. UBXD proteins also constitute the largest family of VCP cofactors and are generally involved in substrate recruitment to VCP, as well as regulation of its activity. UBXD2B (UBX domain-containing protein 2B), also known as NSFL1 cofactor p37 and p97 cofactor p37, is a 331 amino acid protein that contains one UBX domain and one SEP domain. UBXN2B is required for ER and Golgi biogenesis and also plays a role in their maintenance during interphase, as well as their reassembly at the end of mitosis. Through interaction with VCP, UBXN2B forms a complex that has membrane fusion activity. Function: Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity. Subunit: Interacts with VCP. Does not bind ubiquitin (By similarity). Subcellular Location: Nucleus. Cytoplasm; cytosol. Endoplasmic reticulum. Golgi apparatus. Similarity: Belongs to the NSFL1C family. Contains 1 SEP domain. Contains 1 UBX domain. Database links: Entrez Gene: 137886 Human Omim: 610686 Human SwissProt: Q14CS0 Human Unigene: 155572 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
UBX（泛素调节X）结构域是一个80个氨基酸基序，通常存在于某些真核蛋白质的羧基末端。含UBX结构域的蛋白（UBXD），如FAF1、P33、IG1和D8S229 8E，通常参与泛素相关的过程。UBXD蛋白也是VCP辅因子的最大家族，通常参与VCP底物的募集及其活性的调节。UBXD2B(UBX结构域含蛋白2B)，又称NSFL1辅因子p37和p97辅因子p37，是一种331氨基酸蛋白，含有一个UBX结构域和一个SEP结构域。UBXN2B是ER和高尔基体生物发生所必需的，在细胞间期的维持，以及在有丝分裂末期的重组中发挥作用。通过与VCP的相互作用，UBXN2B形成具有膜融合活性的复合物。